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Rabbit Anti-RNF212 antibody (bs-18326R)
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说明书:100ul  200ul
100ul/1380.00元
200ul/2200.00元
大包装/询价
产品编号bs-18326R
英文名称RNF212
中文名称环指蛋白212抗体
别    名LOC285498;FLJ38841; Hypothetical protein LOC285498; OTTHUMP00000147525; Probable E3 SUMO-protein ligase RNF212; RING finger protein 212; RN212_HUMAN; RNF 212; RNF212; ZHP3; ZHP3, C. elegans, homolog of; ZIP3-related protein.  
规格价格100ul/1380元购买    200ul/2200元购买    大包装/询价
说 明 书100ul  200ul
研究领域细胞生物  免疫学  转录调节因子  表观遗传学  环指蛋白  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, 
产品应用ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量33kDa
细胞定位细胞核 细胞浆 
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human RNF212:201-297/297 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

Function:
Key regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement.

Subcellular Location:
Nucleus. Chromosome. Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema.

Similarity:
Contains 1 RING-type zinc finger.

SWISS:
Q495C1

Gene ID:
285498

Database links:

Entrez Gene: 285498 Human

Omim: 612041 Human

SwissProt: Q495C1 Human

Unigene: 248290 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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